91精产品一三三三区免费_东方伊园甸2023官网直达_国外精品成品入入入口苹果应用

12.Precise regulation and visualization of the tumor metabolic microenvironment

Tumor metabolic microenvironment refers to the metabolic interaction between tumor cells and surrounding normal cells (such as immune cells, fibroblasts, vascular endothelial cells, etc.) and extracellular matrix, which affect the growth, invasion, metastasis and drug resistance of tumors. Precise regulation and visualization of the tumor metabolic microenvironment is an emerging antitumor strategy designed to inhibit tumor development by changing the metabolic status of tumor cells and surrounding cells, and monitor the metabolic changes of tumors through imaging techniques. Case of precise regulation and visualization of tumor metabolic microenvironment: By targeting the immune cells in the tumor microenvironment, such as macrophages, dendritic cells, T cells, etc., and regulating their metabolic pathways, such as glucose metabolism, amino acid metabolism, fatty acid metabolism, etc., so as to enhance the ability of the immune system to kill tumors; By targeting fibroblasts in the tumor microenvironment, inhibiting the secretion of factors that promote tumor growth and angiogenesis, such as TGF- β, VE GF, etc., so as to inhibit tumor progression; By targeting the hypoxic and acidic conditions in the tumor microenvironment, using hypoxia-inducible factor (HIF) or carbonic anhydrase (CA) as therapeutic targets or imaging probes, so as to inhibit the adaptive response of the tumor or improve the imaging contrast; By targeting specific metabolites or metabolic enzymes in the tumor microenvironment, such as succinate, fumarate, D-2-hydroxyglutarate (D-2 HG), such as biomarkers or drug carriers, to achieve accurate diagnosis or treatment of specific types or subtypes of tumors.

18915694570

mxenes@163.com

advisory
phone
cro@szbknm.com
Tel:+8618915694570
scan

scan
WeChat

昌黎县| 西昌市| 磴口县| 白银市| 海林市| 化德县| 鲁山县| 通渭县| 沂水县| 增城市|