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The silicon oxide cross-linked micelle drug carrier system is a novel drug vehicle using silicon oxide nanoparticles as cross-linking agents to self-assemble amphiphilic polymers into micelles with core-shell structure, thus achieving efficient drug delivery and release. The silicon oxide cross-linked micelle drug carrier system is highly stable, biocompatible, tunable and functional, and can be used to treat many diseases such as cancer, inflammation and infection.